| Gene | Nucleotide Mutations | Amino Acid Changes |
|---|---|---|
| ORF1ab | C3266T, T6953C, C5387A, 11288:11296 deletion | T1001I, I2230T, A1708D |
| S | A23062T, C23270A, A23402G, C23603A, C23708T, T24505G, G24913C | DEL69-70, DEL144Y, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H |
| N | GAT28279CTA, C28976T | D3L, S235F |
| ORF8 | G28047T, C27971T, A28110G | R52I, Q27_, Y73C |
As figure 3.2 indicates, the majority of B.1.1.7 genomes identified in the US (so far),
were identified by S-gene
target failures (SGTF) in community-based diagnostic PCR testing. Since
it was not an unbiased approach, it does not indicate the true prevalence
of the B117 lineage in the US. This only tells us that the lineage is
present in the US.
P.S: estimates of true prevalence in the US are discussed in
this post